Organic synthesis laboratories frequently store organic solvents, flammable reagents, and strong acids and bases, creating an environment where volatile, flammable vapors can easily accumulate. Flooring and wall surfaces must not only withstand chemical corrosion but also prevent static electricity buildup while complying with explosion-proof safety standards. The primary construction challenges lie in substrate preparation, material selection, detailing at junctions, grounding systems, airtight installation, and compatibility with long-term operation and maintenance.

Ventilation systems for organic synthesis laboratories represent the highest-cost, lowest fault-tolerance, and most difficult-to-retrofit component of full laboratory fit-out works. Their core design objectives are as follows:


1.Timely exhaust flammable and toxic VOC vapors;2.Maintain stable negative indoor pressure to prevent odor leakage to adjacent areas;3.Keep the concentration of organic solvent vapors inside ductwork below the lower explosive limit (LEL);4.Avoid drastic fluctuations in indoor temperature and humidity caused by high-volume exhaust air.
The complete ventilation system consists of six core subsystems: local exhaust ventilation (primarily fume hoods), general room exhaust, makeup air supply, duct piping, waste gas treatment, and automated interlock control. Each subsystem carries unique challenges in design and construction.

Scientific and standardized planning and design are crucial for the safe operation of laboratories, efficient experimentation, and compliant review and acceptance. To meet the construction needs of various laboratories and avoid common design flaws, laboratory construction can follow a streamlined, practical design system that comprehensively considers safety, usability, compliance, and scalability.

The original beams, columns, floors, and window frames of the old factory building could not be altered. The entire process used prefabricated partitions made of machine-made color steel cleanroom panels to divide the area. The modular assembly achieved physical separation between clean and contaminated areas, strictly following the logic of separating clean and contaminated flow of people and materials, without damaging the original main structure of the building, and is compatible with general clean and contaminated separation standards such as GMP, electronic cleanrooms, and food purification.

The visitor access route to the biopharmaceutical workshop has an independent layout and does not pass through the clean production area. The core design logic is that the visitor access route is set as an independent outer perimeter corridor, which is completely isolated from all clean production areas by solid partitions and sealed doors. The flow of people is completely separated from the flow of people and materials in clean production, with no intersections, crossings, or shared buffers/changing rooms/airlocks. At the same time, it meets the requirements of GMP, biosafety, and personnel flow separation.